Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation

Deoptimization of FMDV P1 Region Results in Robust Serotype-Independent Viral Attenuation

Foot-and-mouth disease (FMD), caused by the FMD virus (FMDV), is a highly contagious disease of cloven-hoofed livestock that can have severe economic impacts. Control and prevention strategies, including the development of improved vaccines, are urgently needed to effectively control FMD outbreaks i...

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Bibliographic Details
Main Authors: Gisselle N. Medina, Edward Spinard, Paul A. Azzinaro, Monica Rodriguez-Calzada, Joseph Gutkoska, Anna Kloc, Elizabeth A. Rieder, Bruce E. Taillon, Stephen Mueller, Teresa de los Santos, Fayna Diaz-San Segundo
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
foot-and-mouth disease
FMDV
vaccines
deoptimization
codon-pair bias
picornavirus
Online Access:https://www.mdpi.com/1999-4915/15/6/1332

Internet

https://www.mdpi.com/1999-4915/15/6/1332

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