Role of CCR2+ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium

Role of CCR2+ Myeloid Cells in Inflammation Responses Driven by Expression of a Surfactant Protein-C Mutant in the Alveolar Epithelium

Acute inflammatory exacerbations (AIE) represent precipitous deteriorations of a number of chronic lung conditions, including pulmonary fibrosis (PF), chronic obstructive pulmonary disease and asthma. AIEs are marked by diffuse and persistent polycellular alveolitis that profoundly accelerate lung f...

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Bibliographic Details
Main Authors: Alessandro Venosa, Sophie Cowman, Jeremy Katzen, Yaniv Tomer, Brittnie S. Armstrong, Surafel Mulugeta, Michael F. Beers
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
alveolar type-2 cell
Sftpc I73T surfactant protein-C I73T mutant
idiopathic pulmonary fibrosis
chemokine receptor-2
monocyte-derived alveolar macrophages
acute exacerbation of PF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.665818/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.665818/full

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