Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML

Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML

Abstract Background Cancer patients can achieve dramatic responses to chemotherapy yet retain resistant tumor cells, which ultimately results in relapse. Although xenograft model studies have identified several cellular and molecular features that are associated with chemoresistance in acute myeloid...

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Bibliographic Details
Main Authors: Yongping Zhang, Shuting Jiang, Fuhong He, Yuanyuan Tian, Haiyang Hu, Li Gao, Lin Zhang, Aili Chen, Yixin Hu, Liyan Fan, Chun Yang, Bi Zhou, Dan Liu, Zihan Zhou, Yanxun Su, Lei Qin, Yi Wang, Hailong He, Jun Lu, Peifang Xiao, Shaoyan Hu, Qian-Fei Wang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Genome Biology
Subjects:
Residual tumor cell
Single-cell RNA sequencing
AML
Chemotherapy resistance
Leukemia stem cell
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s13059-023-03031-7

Internet

https://doi.org/10.1186/s13059-023-03031-7

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