Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Abstract Background 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment in colorectal cancer in vitro. Methods SW480 cells were in the present...

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Bibliographic Details
Main Authors: Weilong Yao, Shengtao Zhu, Peng Li, Shutian Zhang
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
5-FU
Colorectal cancer
LATS2
Mitochondrial fission
MIEF1
Apoptosis
Online Access:http://link.springer.com/article/10.1186/s12935-019-0812-3

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http://link.springer.com/article/10.1186/s12935-019-0812-3

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