DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

Long noncoding RNAs (lncRNAs) exhibit diverse functions, including regulation of development. Here, we combine genome-wide mapping of SMAD3 occupancy with expression analysis to identify lncRNAs induced by activin signaling during endoderm differentiation of human embryonic stem cells (hESCs). We fi...

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Bibliographic Details
Main Authors: Kaveh Daneshvar, Joshua V. Pondick, Byeong-Moo Kim, Chan Zhou, Samuel R. York, Jillian A. Macklin, Ameed Abualteen, Bo Tan, Alla A. Sigova, Chelsea Marcho, Kimberly D. Tremblay, Jesse Mager, Michael Y. Choi, Alan C. Mullen
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
endoderm
lncRNA
GSC
DIGIT, SMAD3
TGF-β
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312396

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http://www.sciencedirect.com/science/article/pii/S2211124716312396

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