Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

<p>Abstract</p> <p>Background</p> <p>Abnormal proteostasis due to alterations in protein turnover has been postulated to play a central role in several neurodegenerative diseases. Therefore, the development of techniques to quantify protein turnover in the brain is crit...

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Bibliographic Details
Main Authors: Basak Jacob M, Kim Jungsu, Pyatkivskyy Yuriy, Wildsmith Kristin R, Jiang Hong, Parsadanian Maia, Patterson Bruce W, Bateman Randall J, Holtzman David M
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Molecular Neurodegeneration
Subjects:
Stable isotope
Apolipoprotein E
Amyloid beta
Kinetics
Protein turnover
LDLR
ABCA1
Multiple reaction monitoring mass spectrometry
Online Access:http://www.molecularneurodegeneration.com/content/7/1/14

Internet

http://www.molecularneurodegeneration.com/content/7/1/14

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