<i>NTRK</i> Fusions in Sarcomas: Diagnostic Challenges and Clinical Aspects

<i>NTRK</i> Fusions in Sarcomas: Diagnostic Challenges and Clinical Aspects

Tropomyosin receptor kinase (TK) is encoded by the neurotrophic tyrosine receptor kinase genes (<i>NTRK</i>) 1, 2, and 3, whose activation plays an important role in cell cycle proliferation and survival. Fusions of one of these genes can lead to constitutive activation of TRK, which can...

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Bibliographic Details
Main Authors: Vasiliki Siozopoulou, Evelien Smits, Koen De Winne, Elly Marcq, Patrick Pauwels
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Diagnostics
Subjects:
<i>NTRK</i>
sarcoma
histopathology
TRK-inhibitors
resistance
diagnostic algorithm
Online Access:https://www.mdpi.com/2075-4418/11/3/478

Internet

https://www.mdpi.com/2075-4418/11/3/478

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