Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.

Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.

Accumulation of somatic mutations in antibody variable regions is critical for antibody affinity maturation, with HIV-1 broadly neutralizing antibodies (bnAbs) generally requiring years to develop. We recently found that the rate at which mutations accumulate decreases over time, but the mechanism g...

Full description

Bibliographic Details
Main Authors: Zizhang Sheng, Chaim A Schramm, Mark Connors, Lynn Morris, John R Mascola, Peter D Kwong, Lawrence Shapiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004940&type=printable

Internet

https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004940&type=printable

Similar Items