Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection.

Accumulation of somatic mutations in antibody variable regions is critical for antibody affinity maturation, with HIV-1 broadly neutralizing antibodies (bnAbs) generally requiring years to develop. We recently found that the rate at which mutations accumulate decreases over time, but the mechanism g...

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Detalhes bibliográficos
Principais autores: Zizhang Sheng, Chaim A Schramm, Mark Connors, Lynn Morris, John R Mascola, Peter D Kwong, Lawrence Shapiro
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science (PLoS) 2016-05-01
coleção:PLoS Computational Biology
Acesso em linha:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004940&type=printable