Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

We tested the hypothesis that voluntary wheel running would complement microdystrophin gene therapy to improve muscle function in young mdx mice, a model of Duchenne muscular dystrophy. mdx mice injected with a single dose of AAV9-CK8-microdystrophin or vehicle at age 7 weeks were assigned to three...

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Bibliographic Details
Main Authors: Shelby E. Hamm, Daniel D. Fathalikhani, Katherine E. Bukovec, Adele K. Addington, Haiyan Zhang, Justin B. Perry, Ryan P. McMillan, Michael W. Lawlor, Mariah J. Prom, Mark A. Vanden Avond, Suresh N. Kumar, Kirsten E. Coleman, J.B. Dupont, David L. Mack, David A. Brown, Carl A. Morris, J. Patrick Gonzalez, Robert W. Grange
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
duchenne muscular dystrophy
muscle physiology
muscle pathology
dystrophic grade
voluntary exercise
endurance
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000395

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http://www.sciencedirect.com/science/article/pii/S2329050121000395

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