Trans-dominant inhibition of prion propagation in vitro is not mediated by an accessory cofactor.
Previous studies identified prion protein (PrP) mutants which act as dominant negative inhibitors of prion formation through a mechanism hypothesized to require an unidentified species-specific cofactor termed protein X. To study the mechanism of dominant negative inhibition in vitro, we used recomb...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-07-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2713408?pdf=render |