PBP-A, a cyanobacterial dd-peptidase with high specificity for amidated muropeptides, exhibits pH-dependent promiscuous activity harmful to Escherichia coli
Abstract Penicillin binding proteins (PBPs) are involved in biosynthesis, remodeling and recycling of peptidoglycan (PG) in bacteria. PBP-A from Thermosynechococcus elongatus belongs to a cyanobacterial family of enzymes sharing close structural and phylogenetic proximity to class A β-lactamases. Wi...
Main Authors: | Gol Mohammad Dorrazehi, Matthias Winkle, Martin Desmet, Vincent Stroobant, Gamze Tanriver, Hervé Degand, Damien Evrard, Benoît Desguin, Pierre Morsomme, Jacob Biboy, Joe Gray, Karolina Mitusińska, Artur Góra, Waldemar Vollmer, Patrice Soumillion |
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Format: | Article |
Jezik: | English |
Izdano: |
Nature Portfolio
2024-06-01
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Serija: | Scientific Reports |
Online dostop: | https://doi.org/10.1038/s41598-024-64806-x |
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