Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Personalized whole-brain neural mass models reveal combined Aβ and tau hyperexcitable influences in Alzheimer’s disease

Abstract Neuronal dysfunction and cognitive deterioration in Alzheimer’s disease (AD) are likely caused by multiple pathophysiological factors. However, mechanistic evidence in humans remains scarce, requiring improved non-invasive techniques and integrative models. We introduce personalized AD comp...

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Bibliographic Details
Main Authors: Lazaro M. Sanchez-Rodriguez, Gleb Bezgin, Felix Carbonell, Joseph Therriault, Jaime Fernandez-Arias, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Jenna Stevenson, Thomas K. Karikari, Nicholas J. Ashton, Andréa L. Benedet, Henrik Zetterberg, Kaj Blennow, Gallen Triana-Baltzer, Hartmuth C. Kolb, Pedro Rosa-Neto, Yasser Iturria-Medina
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06217-2

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https://doi.org/10.1038/s42003-024-06217-2

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