Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay

Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay

Objectives: In this study, we aimed to characterize the SARS-CoV-2-specific T cell response detected by the QuantiFERON SARS-CoV-2 research use only assay in terms of accuracy and T cell subsets involved compared with a homemade interferon (IFN)-γ release assay (IGRA).Methods: We evaluated T cell re...

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Bibliographic Details
Main Authors: Alessandra Aiello, Andrea Coppola, Valentina Vanini, Linda Petrone, Gilda Cuzzi, Andrea Salmi, Anna Maria Gerarda Altera, Carla Tortorella, Gina Gualano, Claudio Gasperini, Palma Scolieri, Alessia Beccacece, Serena Vita, Vincenzo Bruzzese, Roberto Lorenzetti, Fabrizio Palmieri, Emanuele Nicastri, Delia Goletti
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:International Journal of Infectious Diseases
Subjects:
QuantiFERON SARS-CoV-2 tubes
Whole-blood
Spike peptides
IFN-γ release assay (IGRA), T cell response
COVID-19
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971222004441

Internet

http://www.sciencedirect.com/science/article/pii/S1201971222004441

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