An MIQP framework for metabolic pathways optimisation and dynamic flux analysis

An MIQP framework for metabolic pathways optimisation and dynamic flux analysis

Dynamic flux analysis methods have been widely used for deciphering complex metabolic fluxes transients. However, many of them require frequent experimental measurements and are ineffective in dealing with under-determined metabolic reaction networks. In this study, we addressed these challenges by...

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Bibliographic Details
Main Authors: Lucas Gerken-Starepravo, Xianfeng Zhu, Bovinille Anye Cho, Fernando Vega-Ramon, Oliver Pennington, Ehecatl Antonio del Río-Chanona, Keju Jing, Dongda Zhang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Digital Chemical Engineering
Subjects:
Dynamic flux analysis
Metabolic network simulation
Mixed-integer quadratic programming (MIQP)
Pathways selection
Yeast astaxanthin production
Online Access:http://www.sciencedirect.com/science/article/pii/S2772508122000023

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http://www.sciencedirect.com/science/article/pii/S2772508122000023

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