Determinants of affinity, specificity, and phase separation in a supramodule from Post-synaptic density protein 95

Summary: The post-synaptic density (PSD) is a phase-separated membraneless compartment of proteins including PSD-95 that undergoes morphological alteration in response to synaptic activity. Here, we investigated the interactome of a three-domain supramodule, PDZ3-SH3-GK (PSG) from PSD-95 using bioin...

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Bibliographic Details
Main Authors: Louise Laursen, Raviteja Inturi, Søren Østergaard, Per Jemth
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013414