FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
cAMP/PKA signalling plays important roles in physiology, but there are a lack of tools to spatially distinguish cAMP. Here the authors present a FRET-based cAMP biosensor they call CUTie that can directly compare cAMP signals at multiple subcellular sites and detect nanoscale heterogeneity in cAMP i...
मुख्य लेखकों: | , , , , , , , , , , , , |
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स्वरूप: | लेख |
भाषा: | English |
प्रकाशित: |
Nature Portfolio
2017-04-01
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श्रृंखला: | Nature Communications |
ऑनलाइन पहुंच: | https://doi.org/10.1038/ncomms15031 |