Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing

Aberrant tissue repair may result in heterotopic ossification (HO), but how this process is regulated by local inflammatory responses is still unclear. Here the authors show, using a mouse burn/trauma model, that TGFβ-producing monocytes/macrophages at the injury site contribute to HO induction, whi...

Full description

Bibliographic Details
Main Authors: Michael Sorkin, Amanda K. Huber, Charles Hwang, William F. Carson, Rajasree Menon, John Li, Kaetlin Vasquez, Chase Pagani, Nicole Patel, Shuli Li, Noelle D. Visser, Yashar Niknafs, Shawn Loder, Melissa Scola, Dylan Nycz, Katherine Gallagher, Laurie K. McCauley, Jiajia Xu, Aaron W. James, Shailesh Agarwal, Stephen Kunkel, Yuji Mishina, Benjamin Levi
Format: Article
Language:English
Published: Nature Portfolio 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14172-4

Internet

https://doi.org/10.1038/s41467-019-14172-4

Similar Items