A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal

A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal

HPV-associated oropharynx carcinoma (HPVOPC) tumors have a relatively low mutational burden. Elucidating the relative contributions of other tumor alterations, such as DNA methylation alterations, alternative splicing events (ASE), and copy number variation (CNV), could provide a deeper understandin...

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Bibliographic Details
Main Authors: Jesse R. Qualliotine, Takuya Nakagawa, Sara Brin Rosenthal, Sayed Sadat, Carmen Ballesteros-Merino, Guorong Xu, Adam Mark, Art Nasamran, J. Silvio Gutkind, Kathleen M. Fisch, Theresa Guo, Bernard A. Fox, Zubair Khan, Alfredo A. Molinolo, Joseph A. Califano
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
network analysis
head and neck squamous cell carcinoma
human papillomavirus
HPV
oropharyngeal neoplasms
epigenetics
Online Access:https://www.mdpi.com/2072-6694/15/17/4379

Internet

https://www.mdpi.com/2072-6694/15/17/4379

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