Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets

Macrophage and fibroblast trajectory inference and crosstalk analysis during myocardial infarction using integrated single-cell transcriptomic datasets

Abstract Background Cardiac fibrosis after myocardial infarction (MI) has been considered an important part of cardiac pathological remodeling. Immune cells, especially macrophages, are thought to be involved in the process of fibrosis and constitute a niche with fibroblasts to promote fibrosis. How...

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Bibliographic Details
Main Authors: Da Ke, Mingzhen Cao, Jian Ni, Yuan Yuan, Jiangyang Deng, Si Chen, Xiujun Dai, Heng Zhou
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Translational Medicine
Subjects:
Myocardial infarction
scRNA-seq
Cardiac fibrosis
Fibroblasts
Macrophages
Online Access:https://doi.org/10.1186/s12967-024-05353-x

Internet

https://doi.org/10.1186/s12967-024-05353-x

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