Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles

Comparative Serum and Brain Pharmacokinetics of Quercetin after Oral and Nasal Administration to Rats as Lyophilized Complexes with β-Cyclodextrin Derivatives and Their Blends with Mannitol/Lecithin Microparticles

Quercetin (Que) is one of the most studied flavonoids with strong antioxidant properties ascribed to its ability to bind free radicals and inactivate them. However, the low solubility of the compound along with its inadequate absorption after oral administration limit its beneficial effects. Que’s c...

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Bibliographic Details
Main Authors: Konstantina Manta, Paraskevi Papakyriakopoulou, Anna Nikolidaki, Evangelos Balafas, Nikolaos Kostomitsopoulos, Sabrina Banella, Gaia Colombo, Georgia Valsami
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceutics
Subjects:
quercetin
cyclodextrins
pharmacokinetics
nose-to-brain transport
nasal powders
Alzheimer’s disease
Online Access:https://www.mdpi.com/1999-4923/15/8/2036

Internet

https://www.mdpi.com/1999-4923/15/8/2036

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