Comparison of Steroidogenic and Ovulation-Inducing Effects of Orthosteric and Allosteric Agonists of Luteinizing Hormone/Chorionic Gonadotropin Receptor in Immature Female Rats

Comparison of Steroidogenic and Ovulation-Inducing Effects of Orthosteric and Allosteric Agonists of Luteinizing Hormone/Chorionic Gonadotropin Receptor in Immature Female Rats

Gonadotropins, including human chorionic gonadotropin (hCG), are used to induce ovulation, but they have a number of side effects, including ovarian hyperstimulation syndrome (OHSS). A possible alternative is allosteric luteinizing hormone (LH)/hCG receptor agonists, including the compound TP4/2 we...

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Bibliographic Details
Main Authors: Kira V. Derkach, Ivan A. Lebedev, Irina Yu. Morina, Andrey A. Bakhtyukov, Alena S. Pechalnova, Viktor N. Sorokoumov, Veronica S. Kuznetsova, Irina V. Romanova, Alexander O. Shpakov
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
ovarian steroidogenesis
ovulation
allosteric agonist
chorionic gonadotropin
luteinizing hormone receptor
immature female rat
Online Access:https://www.mdpi.com/1422-0067/24/23/16618

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https://www.mdpi.com/1422-0067/24/23/16618

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