In vivo Implantation of a Bovine-Derived Collagen Membrane Leads to Changes in the Physiological Cellular Pattern of Wound Healing by the Induction of Multinucleated Giant Cells: An Adverse Reaction?

In vivo Implantation of a Bovine-Derived Collagen Membrane Leads to Changes in the Physiological Cellular Pattern of Wound Healing by the Induction of Multinucleated Giant Cells: An Adverse Reaction?

The present study evaluated the tissue response toward a resorbable collagen membrane derived from bovine achilles tendon (test group) in comparison to physiological wound healing (control group). After subcutaneous implantation in Wistar rats over 30 days, histochemical and immunohistochemical meth...

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Bibliographic Details
Main Authors: Sarah Al-Maawi, Chakorn Vorakulpipat, Anna Orlowska, Tomislav A. Zrnc, Robert A. Sader, C James Kirkpatrick, Shahram Ghanaati
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
multinucleated giant cells
adverse reaction
collagen-based biomaterial
memebrane
regeneration
wound healing
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2018.00104/full

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https://www.frontiersin.org/article/10.3389/fbioe.2018.00104/full

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