Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth

Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.

Bibliographic Details
Main Authors: Linda Sawade, Federica Grandi, Marianna Mignanelli, Genaro Patiño-López, Kerstin Klinkert, Francina Langa-Vives, Roberta Di Guardo, Arnaud Echard, Alessandra Bolino, Volker Haucke
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16696-6

Internet

https://doi.org/10.1038/s41467-020-16696-6

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