Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth
Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16696-6 |
| _version_ | 1818994456756486144 |
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| author | Linda Sawade Federica Grandi Marianna Mignanelli Genaro Patiño-López Kerstin Klinkert Francina Langa-Vives Roberta Di Guardo Arnaud Echard Alessandra Bolino Volker Haucke |
| author_facet | Linda Sawade Federica Grandi Marianna Mignanelli Genaro Patiño-López Kerstin Klinkert Francina Langa-Vives Roberta Di Guardo Arnaud Echard Alessandra Bolino Volker Haucke |
| author_sort | Linda Sawade |
| collection | DOAJ |
| description | Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover. |
| first_indexed | 2024-12-20T20:58:15Z |
| format | Article |
| id | doaj.art-d1e62855b2dc4aa889b4c3bfd2e4dbff |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:58:15Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d1e62855b2dc4aa889b4c3bfd2e4dbff2022-12-21T19:26:47ZengNature PortfolioNature Communications2041-17232020-06-0111111810.1038/s41467-020-16696-6Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growthLinda Sawade0Federica Grandi1Marianna Mignanelli2Genaro Patiño-López3Kerstin Klinkert4Francina Langa-Vives5Roberta Di Guardo6Arnaud Echard7Alessandra Bolino8Volker Haucke9Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10Institute of Experimental Neurology (InSpe), Division of Neuroscience, IRCCS Ospedale San Raffaele, Via Olgettina 60Institute of Experimental Neurology (InSpe), Division of Neuroscience, IRCCS Ospedale San Raffaele, Via Olgettina 60Laboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México, Federico Gómez. C.PMembrane Traffic and Cell Division Lab, Institut Pasteur, UMR3691, CNRS, 25–28 rue du Dr RouxCentre d’Ingénierie Génétique Murine, Institut Pasteur, 25–28 rue du Dr RouxInstitute of Experimental Neurology (InSpe), Division of Neuroscience, IRCCS Ospedale San Raffaele, Via Olgettina 60Membrane Traffic and Cell Division Lab, Institut Pasteur, UMR3691, CNRS, 25–28 rue du Dr RouxInstitute of Experimental Neurology (InSpe), Division of Neuroscience, IRCCS Ospedale San Raffaele, Via Olgettina 60Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Robert-Rössle-Strasse 10Charcot-Marie-Tooth (CMT) is an inherited peripheral neuropathy. Here, the authors show that Rab35 forms a complex with genes implicated in CMT, MTMR13 and MTMR2, which regulates myelin growth by controlling mTORC1 signaling through lipid turnover.https://doi.org/10.1038/s41467-020-16696-6 |
| spellingShingle | Linda Sawade Federica Grandi Marianna Mignanelli Genaro Patiño-López Kerstin Klinkert Francina Langa-Vives Roberta Di Guardo Arnaud Echard Alessandra Bolino Volker Haucke Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth Nature Communications |
| title | Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth |
| title_full | Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth |
| title_fullStr | Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth |
| title_full_unstemmed | Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth |
| title_short | Rab35-regulated lipid turnover by myotubularins represses mTORC1 activity and controls myelin growth |
| title_sort | rab35 regulated lipid turnover by myotubularins represses mtorc1 activity and controls myelin growth |
| url | https://doi.org/10.1038/s41467-020-16696-6 |
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