Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP

Global blood miRNA profiling unravels early signatures of immunogenicity of Ebola vaccine rVSVΔG-ZEBOV-GP

Summary: The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus Disease (EVD). In a study of forty-eight healthy adult volunteers who received either the rVSVΔG-ZEBOV-GP vaccine or placebo, we profiled intracellular microRNAs (miRNAs) from whole blood cells (WB) and circul...

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Main Authors: Eleonora Vianello, Josefine Persson, Björn Andersson, Suzanne van Veen, Thomaz Lüscher Dias, Francesco Santoro, Malin Östensson, Ogonna Obudulu, Christopher Agbajogu, Sara Torkzadeh, Helder I. Nakaya, Donata Medaglini, Claire-Anne Siegrist, Tom H.M. Ottenhoff, Ali M. Harandi, Selidji Todagbe Agnandji, Rafi Ahmed, Jenna Anderson, Floriane Auderset, Philip Bejon, Luisa Borgianni, Jessica Brosnahan, Annalisa Ciabattini, Olivier Engler, Marielle C. Haks, Donald Gray Heppner, Alice Gerlini, Angela Huttner, Peter G. Kremsner, Thomas Monath, Francis Ndungu, Patricia Njuguna, David Pejoski, Mark Page, Gianni Pozzi, Sheri Dubey, Micheal J. Eichberg, Patrícia Gonzalez-Dias, Paulin Ndong Essone, Lumeka Kabwende, Peter Gottfried Kremsner, Helder Nakaya, Sravya S. Nakka, Mariëlle C. Haks, Sylvia Rothenberger
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:iScience
Subjects:
Health sciences
Molecular biology
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223026512

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http://www.sciencedirect.com/science/article/pii/S2589004223026512

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