Assessing and Overcoming Resistance Phenomena against a Genetically Modified Vaccinia Virus in Selected Cancer Cell Lines

Assessing and Overcoming Resistance Phenomena against a Genetically Modified Vaccinia Virus in Selected Cancer Cell Lines

Genetically modified vaccinia viruses (VACVs) have been shown to possess profound oncolytic capabilities. However, tumor cell resistance to VACVs may endanger broad clinical success. Using cell mass assays, viral replication studies, and fluorescence microscopy, we investigated primary resistance ph...

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Bibliographic Details
Main Authors: Susanne Berchtold, Julia Beil, Christian Raff, Irina Smirnow, Martina Schell, Janina D’Alvise, Silvia Gross, Ulrich M. Lauer
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
oncolytic virotherapy
virotherapy resistance
vaccinia virus
NCI-60 tumor cell panel
super cytosine deaminase prodrug system
chemovirotherapy
Online Access:https://www.mdpi.com/1422-0067/21/20/7618

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https://www.mdpi.com/1422-0067/21/20/7618

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