Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes

<p>The long-term objective of this project is to utilize the I-domain protein for the &#945;-subunit of LFA-1 to target drugs to lymphocytes by binding to ICAM receptors on the cell surface. The short-term goal is to provide proof-of-concept that I-domain conjugated to small molecules can...

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Bibliographic Details
Main Author: Prakash Manikwar, Bimo A. Tejo, Heather Shinogle, David S. Moore, Tahl Zimmerman, Francisco Blanco, Teruna J. Siahaan
Format: Article
Language:English
Published: Ivyspring International Publisher 2011-01-01
Series:Theranostics
Online Access:http://www.thno.org/v01p0277.htm