TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

TCR meta-clonotypes for biomarker discovery with tcrdist3 enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs

T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of TCR clonotypes as clinical biomarkers. We propose a new framework...

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Bibliographic Details
Main Authors: Koshlan Mayer-Blackwell, Stefan Schattgen, Liel Cohen-Lavi, Jeremy C Crawford, Aisha Souquette, Jessica A Gaevert, Tomer Hertz, Paul G Thomas, Philip Bradley, Andrew Fiore-Gartland
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
T cell receptor
immune repertoire
SARS-CoV-2
software
biomarkers
Online Access:https://elifesciences.org/articles/68605

Internet

https://elifesciences.org/articles/68605

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