A Stochastic Intracellular Model of Anthrax Infection With Spore Germination Heterogeneity

A Stochastic Intracellular Model of Anthrax Infection With Spore Germination Heterogeneity

We present a stochastic mathematical model of the intracellular infection dynamics of Bacillus anthracis in macrophages. Following inhalation of B. anthracis spores, these are ingested by alveolar phagocytes. Ingested spores then begin to germinate and divide intracellularly. This can lead to the e...

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Bibliographic Details
Main Authors: Bevelynn Williams, Martín López-García, Joseph J. Gillard, Thomas R. Laws, Grant Lythe, Jonathan Carruthers, Thomas Finnie, Carmen Molina-París
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Bacillus anthracis
Markov process
intracellular model
spore germination
rupture size distribution
approximate Bayesian computation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.688257/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.688257/full

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