Integrated analysis revealed hypoxia signatures and LDHA related to tumor cell dedifferentiation and unfavorable prognosis in pancreatic adenocarcinoma

Integrated analysis revealed hypoxia signatures and LDHA related to tumor cell dedifferentiation and unfavorable prognosis in pancreatic adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous cancer with limited understanding of its classification and tumor microenvironment. Here, by analyzing single-nucleus RNA sequencing of 43, 817 tumor cells from 15 PDAC tumors and non-tumor, we find that hypoxia signatures were hetero...

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Bibliographic Details
Main Authors: Mingwei Dong, Rong Tang, Wei Wang, Jin Xu, Jiang Liu, Chen Liang, Jie Hua, Qingcai Meng, Xianjun Yu, Bo Zhang, Si Shi
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Translational Oncology
Subjects:
Pancreatic adenocarcinoma
Hypoxia
TP53
Keratinization
TP63
LDHA
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523323000785

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http://www.sciencedirect.com/science/article/pii/S1936523323000785

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