Thermal analysis of ligand-DNA interaction: determination of binding parameters

Thermal analysis of ligand-DNA interaction: determination of binding parameters

The review discusses the methods of thermodynamic analysis of reactions of non-covalent binding of biologically active compounds with DNA, which is a key constituent of cell chromatin. Knowledge of thermodynamic profile of ligand binding with nucleic acids is important for understanding the mechanis...

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Bibliographic Details
Main Authors: Ekaterina Bereznyak, Natalia Gladkovskaya, Evgeniy Dukhopelnykov, Anastasiya Gerus, Anastasiya Lantushenko, Maxim Evstigneev
Format: Article
Language:English
Published: AIMS Press 2015-09-01
Series:AIMS Biophysics
Subjects:
DNA
ligand
melting thermodynamics
binding parameters
calorimetry
UV-spectroscopy
Online Access:http://www.aimspress.com/biophysics/article/410/fulltext.html

Internet

http://www.aimspress.com/biophysics/article/410/fulltext.html

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