Melanoma Derived Exosomes Amplify Radiotherapy Induced Abscopal Effect via IRF7/I‐IFN Axis in Macrophages

Melanoma Derived Exosomes Amplify Radiotherapy Induced Abscopal Effect via IRF7/I‐IFN Axis in Macrophages

Abstract Radiotherapy (RT) can induce tumor regression outside the irradiation field, known as the abscopal effect. However, the detailed underlying mechanisms remain largely unknown. A tumor‐bearing mouse model is successfully constructed by inducing both subcutaneous tumors and lung metastases. Si...

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Bibliographic Details
Main Authors: Lu Wang, Kangjie Shen, Zixu Gao, Ming Ren, Chenlu Wei, Yang Yang, Yinlam Li, Yu Zhu, Simin Zhang, Yiteng Ding, Tianyi Zhang, Jianrui Li, Ming Zhu, Shaoluan Zheng, Yanwen Yang, Shisuo Du, Chuanyuan Wei, Jianying Gu
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Advanced Science
Subjects:
abscopal effect
I‐IFNs
IRF7
melanoma
radiotherapy
Online Access:https://doi.org/10.1002/advs.202304991

Internet

https://doi.org/10.1002/advs.202304991

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