A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis

A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis

Summary: Refractory and relapsed B cell lymphomas are often driven by the difficult-to-target oncogene MYC. Here, we report that high MYC expression stimulates proliferation and protects B lymphoma cells from apoptosis under normal oxidative stress levels and that compounds including N-acetylcystein...

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Bibliographic Details
Main Authors: Haidong Yao, Xue Chen, Ting Wang, Muhammad Kashif, Xi Qiao, Elin Tüksammel, Lars-Gunnar Larsson, Sam Okret, Volkan I. Sayin, Hong Qian, Martin O. Bergo
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009725

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http://www.sciencedirect.com/science/article/pii/S2211124723009725

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