Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

Human embryonic stem cell (hESC)-derived dopamine neurons are currently moving toward clinical use for Parkinson’s disease (PD). However, the timing and extent at which stem cell-derived neurons functionally integrate into existing host neural circuitry after transplantation remain largely unknown....

Full description

Bibliographic Details
Main Authors: Shane Grealish, Andreas Heuer, Tiago Cardoso, Agnete Kirkeby, Marie Jönsson, Jenny Johansson, Anders Björklund, Johan Jakobsson, Malin Parmar
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111500123X

Internet

http://www.sciencedirect.com/science/article/pii/S221367111500123X

Similar Items