Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis

Phenotypic correlates of serum neurofilament light chain levels in amyotrophic lateral sclerosis

ObjectiveTo investigate the relationship between serum levels of the neuroaxonal degeneration biomarker neurofilament light chain (NFL) and phenotype in ALS.Materials and methodsSerum NFL (sNFL) concentration was quantified in 209 ALS patients and 46 neurologically healthy controls (NHCs).ResultssNF...

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Bibliographic Details
Main Authors: Federico Verde, Ilaria Milone, Eleonora Colombo, Alessio Maranzano, Federica Solca, Silvia Torre, Alberto Doretti, Francesco Gentile, Arianna Manini, Ruggero Bonetti, Silvia Peverelli, Stefano Messina, Luca Maderna, Claudia Morelli, Barbara Poletti, Antonia Ratti, Vincenzo Silani, Nicola Ticozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
motor neuron disease (MND)
neurofilament light chain (NFL)
axon
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1132808/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1132808/full

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