Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo

Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo

Osteoporosis deteriorates bone mass and biomechanical strength and is life-threatening to the elderly. In this study, we show that methyl 3,4-dihydroxybenzoate (MDHB), an antioxidant small-molecule compound extracted from natural plants, inhibits receptor activator of nuclear factor-κB (NF-κB) ligan...

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Bibliographic Details
Main Authors: Huang Zhaobo, Jiang Zenghui, Zheng Zeyu, Zhang Xuyang, Wei Xiaoan, Chen Jian, Zhao Fengdong
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-08-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
methyl 3,4-dihydroxybenzoate
osteoclastogenesis
Nrf2
osteoclast
osteoporosis
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022087

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022087

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