Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart

Progressive tissue remodeling after myocardial infarction (MI) promotes cardiac arrhythmias. This process is well studied in young animals, but little is known about pro-arrhythmic changes in aged animals. Senescent cells accumulate with age and accelerate age-associated diseases. Senescent cells in...

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Bibliographic Details
Main Authors: Brett C Baggett, Kevin R Murphy, Elif Sengun, Eric Mi, Yueming Cao, Nilufer N Turan, Yichun Lu, Lorraine Schofield, Tae Yun Kim, Anatoli Y Kabakov, Peter Bronk, Zhilin Qu, Patrizia Camelliti, Patrycja Dubielecka, Dmitry Terentyev, Federica del Monte, Bum-Rak Choi, John Sedivy, Gideon Koren
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
cardiac arrhythmia
sudden cardiac death
myocardial infarction
senescence
Online Access:https://elifesciences.org/articles/84088

Internet

https://elifesciences.org/articles/84088

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