A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease (PD), the leading causes of dementia. These neurological disorders are characterized by the accumulation of misfolded proteins such as amyloid-ß (Aß), tau protein and α-synuclein, contributing to mit...

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Bibliographic Details
Main Authors: Sarmistha Saha, Brigitta Buttari, Elisabetta Profumo, Paolo Tucci, Luciano Saso
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer's disease
Parkinson's disease
Nrf2 signaling pathway
neuroinflammation
oxidative stress
Keap1
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.787258/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.787258/full

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