An inducible and reversible mouse genetic rescue system.

An inducible and reversible mouse genetic rescue system.

Inducible and reversible regulation of gene expression is a powerful approach for uncovering gene function. We have established a general method to efficiently produce reversible and inducible gene knockout and rescue in mice. In this system, which we named iKO, the target gene can be turned on and...

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Bibliographic Details
Main Authors: Hongkui Zeng, Kyoji Horie, Linda Madisen, Maria N Pavlova, Galina Gragerova, Alex D Rohde, Brian A Schimpf, Yuqiong Liang, Ethan Ojala, Farah Kramer, Patricia Roth, Olga Slobodskaya, Io Dolka, Eileen A Southon, Lino Tessarollo, Karin E Bornfeldt, Alexander Gragerov, George N Pavlakis, George A Gaitanaris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2346557?pdf=render

Internet

http://europepmc.org/articles/PMC2346557?pdf=render

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