Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer

Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer

Abstract Background Numerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional multi-region sampling strategies do not preserve the spatial details of samples, and thus, the potential influences...

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Bibliographic Details
Main Authors: Chen Yang, Senquan Zhang, Zhuoan Cheng, Zhicheng Liu, Linmeng Zhang, Kai Jiang, Haigang Geng, Ruolan Qian, Jun Wang, Xiaowen Huang, Mo Chen, Zhe Li, Wenxin Qin, Qiang Xia, Xiaonan Kang, Cun Wang, Hualian Hang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Genome Medicine
Subjects:
Hepatocellular carcinoma
Intra-tumor heterogeneity
Immunotherapy
Prognostication
Online Access:https://doi.org/10.1186/s13073-022-01143-6

Internet

https://doi.org/10.1186/s13073-022-01143-6

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