Genetic Variation Putatively Associated with <i>Mycobacterium tuberculosis</i> Resistance to Perchlozone, a New Thiosemicarbazone: Clues from Whole Genome Sequencing and Implications for Treatment of Multidrug-Resistant Tuberculosis

Genetic Variation Putatively Associated with <i>Mycobacterium tuberculosis</i> Resistance to Perchlozone, a New Thiosemicarbazone: Clues from Whole Genome Sequencing and Implications for Treatment of Multidrug-Resistant Tuberculosis

Perchlozone ([PCZ] 4-thioureido-iminomethylpyridinium perchlorate) is a new thiosemicarbazone approved for the treatment of multidrug-resistant tuberculosis (MDR-TB) in Russia and some other countries. The <i>ethA</i> and <i>hadABC</i> mutations may confer PCZ resistance. At...

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Bibliographic Details
Main Authors: Igor Mokrousov, Anna Vyazovaya, Gulnora Akhmedova, Natalia Solovieva, Eugeni Turkin, Viacheslav Zhuravlev
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Antibiotics
Subjects:
<i>Mycobacterium tuberculosis</i>
drug resistance
perchlozone
thiosemicarbazone
ethionamide
<i>ethA</i>
Online Access:https://www.mdpi.com/2079-6382/9/10/669

Internet

https://www.mdpi.com/2079-6382/9/10/669

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