CONET: copy number event tree model of evolutionary tumor history for single-cell data

CONET: copy number event tree model of evolutionary tumor history for single-cell data

Abstract Copy number alterations constitute important phenomena in tumor evolution. Whole genome single-cell sequencing gives insight into copy number profiles of individual cells, but is highly noisy. Here, we propose CONET, a probabilistic model for joint inference of the evolutionary tree on copy...

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Bibliographic Details
Main Authors: Magda Markowska, Tomasz Cąkała, BłaŻej Miasojedow, Bogac Aybey, Dilafruz Juraeva, Johanna Mazur, Edith Ross, Eike Staub, Ewa Szczurek
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Genome Biology
Subjects:
Copy number alterations
Tumor evolution
Single-cell sequencing
Probabilistic model
MCMC sampling
Online Access:https://doi.org/10.1186/s13059-022-02693-z

Internet

https://doi.org/10.1186/s13059-022-02693-z

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