Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis

Role of TET dioxygenases in the regulation of both normal and pathological hematopoiesis

Abstract The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly found to be mutated in age-related clonal hematopoiesis and hematopoietic malignancies. TET2 mutation causes abnormal...

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Bibliographic Details
Main Authors: Kanak Joshi, Lei Zhang, Peter Breslin S.J., Ameet R. Kini, Jiwang Zhang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TET2
Concurring mutations
HSPCs
Self-renewal
Differentiation
MDS
Online Access:https://doi.org/10.1186/s13046-022-02496-x

Internet

https://doi.org/10.1186/s13046-022-02496-x

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