Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes

Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes

OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on the surface of activated T cells. Upon interaction with its cognate ligand, OX40L, OX40 transmits costimulatory signals to antigen-primed T cells, promoting their activation, differentiation, and survival—process...

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Bibliographic Details
Main Authors: Ayaka Sato, Hodaka Nagai, Ayano Suzuki, Aya Ito, Shimpei Matsuyama, Nagito Shibui, Masashi Morita, Mari Hikosaka-Kuniishi, Naoto Ishii, Takanori So
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
OX40L
OX40
co-stimulation
T cell
TNF superfamily
TNF receptor superfamily
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473815/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1473815/full

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