A Novel Antithrombocytopenia Agent, <i>Rhizoma cibotii</i>, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways

A Novel Antithrombocytopenia Agent, <i>Rhizoma cibotii</i>, Promotes Megakaryopoiesis and Thrombopoiesis through the PI3K/AKT, MEK/ERK, and JAK2/STAT3 Signaling Pathways

Background: <i>Cibotii rhizoma (CR)</i> is a famous traditional Chinese medicine (TCM) used to treat bleeding, rheumatism, lumbago, etc. However, its therapeutic effects and mechanism against thrombocytopenia are still unknown so far. In the study, we investigated the effects of aqueous...

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Bibliographic Details
Main Authors: Wang Chen, Linjie Zhu, Long Wang, Jing Zeng, Min Wen, Xiyan Xu, LiLe Zou, Feihong Huang, Qianqian Huang, Dalian Qin, Qibing Mei, Jing Yang, Qiaozhi Wang, Jianming Wu
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
thrombocytopenia
<i>Cibotii rhizoma</i>
megakaryocyte differentiation
network pharmacology
PI3K/AKT
MEK/ERK
Online Access:https://www.mdpi.com/1422-0067/23/22/14060

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https://www.mdpi.com/1422-0067/23/22/14060

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