Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature Dependent Allosteric Activation

Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature Dependent Allosteric Activation

The enzyme imidazole glycerol phosphate synthase (IGPS) is a model for studies of long-range allosteric regulation in enzymes. Binding of the allosteric effector ligand N'-[5'-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide (PRFAR) stimulates millisecond (ms) time...

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Bibliographic Details
Main Authors: George P. Lisi, Allen A. Currier, J. Patrick Loria
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
allostery
enzyme dynamics
relaxation dispersion
thermophile
NMR
Online Access:http://journal.frontiersin.org/article/10.3389/fmolb.2018.00004/full

Internet

http://journal.frontiersin.org/article/10.3389/fmolb.2018.00004/full

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