The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent

The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent

IntroductionIn calcium electroporation (CaEP), electroporation enables the cellular uptake of supraphysiological concentrations of Ca2+, causing the induction of cell death. The effectiveness of CaEP has already been evaluated in clinical trials; however, confirmatory preclinical studies are still n...

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Bibliographic Details
Main Authors: Barbara Lisec, Bostjan Markelc, Katja Ursic Valentinuzzi, Gregor Sersa, Maja Cemazar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
calcium electroporation
electrochemotherapy (ECT)
gene electrotransfer (GET)
interleukin 12 (IL12)
murine tumor models
bleomycin (BLM)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189960/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1189960/full

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