The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling

The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling

Abstract Background Cholangiocarcinoma (CCA) is a highly malignant cancer of the biliary tract with poor prognosis. Further mechanistic insights into the molecular mechanisms of CCA are needed to develop more effective target therapy. Methods The expression of the histone lysine acetyltransferase KA...

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Bibliographic Details
Main Authors: Wenbo Ma, Jinqiang Zhang, Weina Chen, Nianli Liu, Tong Wu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
KAT2B
Histone acetyltransferase
Cholangiocarcinoma
NF2
YAP
Online Access:https://doi.org/10.1186/s13046-024-03036-5

Internet

https://doi.org/10.1186/s13046-024-03036-5

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