From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid
Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a cont...
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| Format: | Article |
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MDPI AG
2014-06-01
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| Series: | Crystals |
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| Online Access: | http://www.mdpi.com/2073-4352/4/2/123 |
| _version_ | 1798026191858302976 |
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| author | Kate Wittering Josh King Lynne H. Thomas Chick C. Wilson |
| author_facet | Kate Wittering Josh King Lynne H. Thomas Chick C. Wilson |
| author_sort | Kate Wittering |
| collection | DOAJ |
| description | Two new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk samples shown to be representative of the multi-component product phase, by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. Turbidity measurements are shown to be a valuable process analytical technology probe for characterising the initial stages of molecular complex formation in solution. The significance of these findings for scale-up of crystallisation of multi-component molecular materials and for future transfer into continuous cooling crystallisation is discussed. |
| first_indexed | 2024-04-11T18:31:24Z |
| format | Article |
| id | doaj.art-d21e4537410f4340a3645b1b1a19e454 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-04-11T18:31:24Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-d21e4537410f4340a3645b1b1a19e4542022-12-22T04:09:27ZengMDPI AGCrystals2073-43522014-06-014212314010.3390/cryst4020123cryst4020123From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic AcidKate Wittering0Josh King1Lynne H. Thomas2Chick C. Wilson3Department of Chemistry, University of Bath, Bath, BA2 7AY, UKDepartment of Chemistry, University of Bath, Bath, BA2 7AY, UKDepartment of Chemistry, University of Bath, Bath, BA2 7AY, UKDepartment of Chemistry, University of Bath, Bath, BA2 7AY, UKTwo new multi-component molecular complexes of cytosine and 5-fluorocytosine with 4-chloro-3,5-dinitrobenzoic acid are presented. Materials synthesis was achieved initially by evaporative crystallisation and the crystal structures determined. The process was then successfully transferred into a controlled small scale cooling crystallisation environment, with bulk samples shown to be representative of the multi-component product phase, by powder X-ray diffraction (PXRD) and differential scanning calorimetry (DSC) methods. Turbidity measurements are shown to be a valuable process analytical technology probe for characterising the initial stages of molecular complex formation in solution. The significance of these findings for scale-up of crystallisation of multi-component molecular materials and for future transfer into continuous cooling crystallisation is discussed.http://www.mdpi.com/2073-4352/4/2/123molecular complexesmulti-component crystallisationcontinuous manufacturing and crystallisationcooling crystallisationprocess analytical technologiesturbidity measurements |
| spellingShingle | Kate Wittering Josh King Lynne H. Thomas Chick C. Wilson From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid Crystals molecular complexes multi-component crystallisation continuous manufacturing and crystallisation cooling crystallisation process analytical technologies turbidity measurements |
| title | From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid |
| title_full | From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid |
| title_fullStr | From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid |
| title_full_unstemmed | From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid |
| title_short | From Evaporative to Cooling Crystallisation: An Initial Co-Crystallisation Study of Cytosine and Its Fluorinated Derivative with 4-chloro-3,5-dinitrobenzoic Acid |
| title_sort | from evaporative to cooling crystallisation an initial co crystallisation study of cytosine and its fluorinated derivative with 4 chloro 3 5 dinitrobenzoic acid |
| topic | molecular complexes multi-component crystallisation continuous manufacturing and crystallisation cooling crystallisation process analytical technologies turbidity measurements |
| url | http://www.mdpi.com/2073-4352/4/2/123 |
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