The Hypertensive Effect of Amphotericin B-Containing Liposomes (Abelcet) in Mice: Dissecting the Roles of C3a and C5a Anaphylatoxins, Macrophages and Thromboxane

The Hypertensive Effect of Amphotericin B-Containing Liposomes (Abelcet) in Mice: Dissecting the Roles of C3a and C5a Anaphylatoxins, Macrophages and Thromboxane

Liposomal amphotericin B (Abelcet) can cause infusion (anaphylactoid) reactions in patients whose mechanism is poorly understood. Here, we used mice to investigate the role of complement (C) receptors and the cellular sources of vasoactive mediators in these reactions. Anesthetized male NMRI and thr...

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Bibliographic Details
Main Authors: Erik Őrfi, László Hricisák, László Dézsi, Péter Hamar, Zoltán Benyó, János Szebeni, Gábor Szénási
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomedicines
Subjects:
infusion reaction
cobra venom factor
platelets
granulocytes
Online Access:https://www.mdpi.com/2227-9059/10/7/1764

Internet

https://www.mdpi.com/2227-9059/10/7/1764

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